Issue 25, 2020

Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy

Abstract

Nanoparticle-enhanced assays read by high-magnification dark-field microscopy require time-intensive analysis methods subject to selection bias, which can be resolved by using low magnification dark-field assays (LMDFA), at the cost of reduced sensitivity. We have simulated and experimentally validated a tunable linker-based signal amplification strategy yielding 6-fold enhanced LMDFA sensitivity.

Graphical abstract: Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy

  • This article is part of the themed collection: Biosensors

Supplementary files

Article information

Article type
Communication
Submitted
08 feb. 2020
Accepted
19 maí 2020
First published
19 maí 2020

J. Mater. Chem. B, 2020,8, 5416-5419

Author version available

Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy

D. Sun, L. Yang, C. J. Lyon and T. Hu, J. Mater. Chem. B, 2020, 8, 5416 DOI: 10.1039/D0TB00350F

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