Issue 22, 2018

DNA interactions of non-chelating tinidazole-based coordination compounds and their structural, redox and cytotoxic properties

Abstract

Novel tinidazole (tnz) coordination compounds of different geometries were synthesised, whose respective solid-state packing appears to be driven by inter- and intramolecular lone pair⋯π interactions. The copper(II) compounds exhibit interesting redox properties originating from both the tnz and the metal ions. These complexes interact with DNA through two distinct ways, namely via electrostatic interactions or/and groove binding, and they can mediate the generation of ROS that damage the biomolecule. Cytotoxic studies revealed an interesting activity of the dinuclear compound [Cu(tnz)2(μ-Cl)Cl]27, which is further more efficient towards cancer cells, compared with normal cells.

Graphical abstract: DNA interactions of non-chelating tinidazole-based coordination compounds and their structural, redox and cytotoxic properties

Supplementary files

Article information

Article type
Paper
Submitted
22 feb. 2018
Accepted
09 maí 2018
First published
09 maí 2018

Dalton Trans., 2018,47, 7551-7560

DNA interactions of non-chelating tinidazole-based coordination compounds and their structural, redox and cytotoxic properties

R. Castro-Ramírez, N. Ortiz-Pastrana, A. B. Caballero, M. T. Zimmerman, B. S. Stadelman, A. A. E. Gaertner, J. L. Brumaghim, L. Korrodi-Gregório, R. Pérez-Tomás, P. Gamez and N. Barba-Behrens, Dalton Trans., 2018, 47, 7551 DOI: 10.1039/C8DT00716K

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