Issue 8, 2015

Copper(i) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

Abstract

Copper(I) coordinating ligands in the Alzheimer's disease context have remained unexplored, despite the biological relevance of this redox state of the copper ion. Here, we show that the PTA ligand can remove copper from Aβ, prevent reactive oxygen species production and oligomer formation, two deleterious events in the disease's etiology.

Graphical abstract: Copper(i) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

Supplementary files

Article information

Article type
Communication
Submitted
18 mar. 2015
Accepted
09 apr. 2015
First published
10 apr. 2015

Metallomics, 2015,7, 1229-1232

Author version available

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