Remarkably enhanced luminol chemiluminescence with a manganese porphyrin-based metal–organic framework for the sensitive detection of dopamine

Abstract

The unique redox transition between Mn(III)-porphyrin and Mn(IV)-porphyrin centers confers exceptional catalytic properties to Mn-porphyrinic frameworks. In this study, we synthesized Mn-based metal–organic frameworks (Mn-MOFs) via a facile one-pot method using manganese(II) chloride tetrahydrate and 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP) as the ligand. The resulting Mn-MOFs exhibited unprecedented peroxidase-mimetic activity, enhancing luminol/H₂O₂ chemiluminescence (CL) by over 1200-fold. Capitalizing on the selective quenching effect of dopamine on the Mn-MOFs/luminol/H₂O₂ system, we developed a rapid CL analytical strategy with a linear detection range of 5–1000 nM and a detection limit of 3.95 nM (S/N = 3). Furthermore, this method was successfully applied for the quantitative determination of dopamine in serum samples, achieving a recovery rate of 98.3%–104.4%. These findings highlight the potential of Mn-porphyrin-based MOFs as efficient catalysts in CL detection platforms, paving the way for their broader application in bioanalytical sensing.