Issue 3, 2024

DNA-functionalized metal or metal-containing nanoparticles for biological applications

Abstract

The conjugation of DNA molecules with metal or metal-containing nanoparticles (M/MC NPs) has resulted in a number of new hybrid materials, enabling a diverse range of novel biological applications in nanomaterial assembly, biosensor development, and drug/gene delivery. In such materials, the molecular recognition, gene therapeutic, and structure-directing functions of DNA molecules are coupled with M/MC NPs. In turn, the M/MC NPs have optical, catalytic, pore structure, or photodynamic/photothermal properties, which are beneficial for sensing, theranostic, and drug loading applications. This review focuses on the different DNA functionalization protocols available for M/MC NPs, including gold NPs, upconversion NPs, metal–organic frameworks, metal oxide NPs and quantum dots. The biological applications of DNA-functionalized M/MC NPs in the treatment or diagnosis of cancers are discussed in detail.

Graphical abstract: DNA-functionalized metal or metal-containing nanoparticles for biological applications

Article information

Article type
Perspective
Submitted
29 okt. 2023
Accepted
05 des. 2023
First published
07 des. 2023

Dalton Trans., 2024,53, 839-850

DNA-functionalized metal or metal-containing nanoparticles for biological applications

B. Liu, H. Duan, Z. Liu, Y. Liu and H. Chu, Dalton Trans., 2024, 53, 839 DOI: 10.1039/D3DT03614F

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