Issue 46, 2023

Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review

Abstract

Spiro-heterocycles have received special attention in medicinal chemistry because of their promising biological activity. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. Spiro heterocycles such as spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives have been found to exhibit diversified biological and pharmacological activity in addition to their therapeutic properties. In view of these facts, we decided in this review to present representative synthetic approaches of the aforementioned spiro heterocycles, especially in the past 20 years.

Graphical abstract: Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review

Article information

Article type
Review Article
Submitted
05 sep. 2023
Accepted
24 okt. 2023
First published
07 nóv. 2023
This article is Open Access
Creative Commons BY license

RSC Adv., 2023,13, 32786-32823

Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review

M. B. Alshammari, A. A. Aly, A. Ahmad, A. B. Brown and A. H. Mohamed, RSC Adv., 2023, 13, 32786 DOI: 10.1039/D3RA06054C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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