Issue 30, 2022

Metal–organic frameworks as a therapeutic strategy for lung diseases

Abstract

Lung diseases remain a global burden today. Lower respiratory tract infections alone cause more than 3 million deaths worldwide each year and are on the rise every year. In particular, with coronavirus disease raging worldwide since 2019, we urgently require a treatment for lung disease. Metal organic frameworks (MOFs) have a broad application prospect in the biomedical field due to their remarkable properties. The unique properties of MOFs allow them to be applied as delivery materials for different drugs; diversified structural design endows MOFs with diverse functions; and they can be designed as various MOF-drug synergistic systems. This review concentrates on the synthesis design and applications of MOF based drugs against lung diseases, and discusses the possibility of preparing MOF-based inhalable formulations. Finally, we discuss the chances and challenges of using MOFs for targeting lung diseases in clinical practice.

Graphical abstract: Metal–organic frameworks as a therapeutic strategy for lung diseases

Article information

Article type
Review Article
Submitted
29 mar. 2022
Accepted
20 jún. 2022
First published
27 jún. 2022

J. Mater. Chem. B, 2022,10, 5666-5695

Metal–organic frameworks as a therapeutic strategy for lung diseases

Y. Zheng, Y. Zhao, M. Bai, H. Gu and X. Li, J. Mater. Chem. B, 2022, 10, 5666 DOI: 10.1039/D2TB00690A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements