Issue 23, 2022

De novo designed peptides form a highly catalytic ordered nanoarchitecture on a graphite surface

Abstract

Here we demonstrate that short peptides, de novo designed from first principles, self-assemble on the surface of graphite to produce a highly robust and catalytic nanoarchitecture, which promotes peroxidation reactions with activities that rival those of natural enzymes in both single and multi-substrate reactions. These designable peptides recapitulate the symmetry of the underlying graphite surface and act as molecular scaffolds to immobilize hemin molecules on the electrode in a hierarchical self-assembly manner. The highly ordered and uniform hybrid graphite–peptide–hemin nanoarchitecture shows the highest faradaic efficiency of any hybrid electrode reported. Given the explosive growth of the types of chemical reactions promoted by self-assembled peptide materials, this new approach to creating complex electrocatalytic assemblies will yield highly efficient and practically applicable electrocatalysts.

Graphical abstract: De novo designed peptides form a highly catalytic ordered nanoarchitecture on a graphite surface

Supplementary files

Article information

Article type
Paper
Submitted
18 mar. 2022
Accepted
09 maí 2022
First published
26 maí 2022
This article is Open Access
Creative Commons BY license

Nanoscale, 2022,14, 8326-8331

De novo designed peptides form a highly catalytic ordered nanoarchitecture on a graphite surface

W. Luo, H. Noguchi, C. Chen, Y. Nakamura, C. Homma, O. Zozulia, I. V. Korendovych and Y. Hayamizu, Nanoscale, 2022, 14, 8326 DOI: 10.1039/D2NR01507B

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