Issue 2, 2022

PEGylation of silver nanoparticles by physisorption of cyclic poly(ethylene glycol) for enhanced dispersion stability, antimicrobial activity, and cytotoxicity

Abstract

Silver nanoparticles (AgNPs) are practically valuable in biological applications. However, no steady PEGylation has been established, which is essential for internal use in humans or animals. In this study, cyclic PEG (c-PEG) without any chemical inhomogeneity is physisorbed onto AgNPs to successfully PEGylate and drastically enhance the dispersion stability against physiological conditions, white light, and high temperature. In contrast, linear HO–PEG–OH and MeO–PEG–OMe do not confer stability to AgNPs, and HS–PEG–OMe, which is often used for gold nanoparticles, sulfidates the surface to considerably degrade the properties. TEM shows an essentially intact nanostructure of c-PEG-physisorbed AgNPs even after heating at 95 °C, while complete disturbance is observed for other AgNPs. Molecular weight- and concentration-dependent stabilization by c-PEG is investigated, and DLS and ζ-potential measurements prove the formation of a c-PEG layer on the surface of AgNPs. Furthermore, c-PEG-physisorbed AgNPs exhibit persistent antimicrobial activity and cytotoxicity.

Graphical abstract: PEGylation of silver nanoparticles by physisorption of cyclic poly(ethylene glycol) for enhanced dispersion stability, antimicrobial activity, and cytotoxicity

Supplementary files

Article information

Article type
Paper
Submitted
29 sep. 2021
Accepted
11 nóv. 2021
First published
12 nóv. 2021
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2022,4, 532-545

PEGylation of silver nanoparticles by physisorption of cyclic poly(ethylene glycol) for enhanced dispersion stability, antimicrobial activity, and cytotoxicity

O. J. Oziri, Y. Wang, T. Watanabe, S. Uno, M. Maeki, M. Tokeshi, T. Isono, K. Tajima, T. Satoh, S. Sato, Y. Miura and T. Yamamoto, Nanoscale Adv., 2022, 4, 532 DOI: 10.1039/D1NA00720C

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