Issue 14, 2022

Supramolecular cancer photoimmunotherapy based on precise peptide self-assembly design

Abstract

Combinational photoimmunotherapy (PIT) is considered to be an ideal strategy for the treatment of highly recurrent and metastatic cancer, because it can ablate the primary tumor and provide in situ an autologous tumor vaccine to induce the host immune response, ultimately achieving the goal of controlling tumor growth and distal metastasis. Significant efforts have been devoted to enhancing the immune response caused by phototherapy-eliminated tumors. Recently, supramolecular PIT nanoagents based on precise peptide self-assembly design have been employed to improve the efficacy of photoimmunotherapy by utilizing the stability, targeting capability and flexibility of drugs, increasing tumor immunogenicity and realizing the synergistic amplification of immune effects through multiple pathways and collaborative strategy. This review summarizes peptide-based supramolecular PIT nanoagents for phototherapy-synergized cancer immunotherapy and its progress in enhancing the effect of photoimmunotherapy, especially focusing on the design of peptide-based PIT nanoagents, the progress of bioactive peptides combined photoimmunotherapy, and the synergistic immune-response mechanism.

Graphical abstract: Supramolecular cancer photoimmunotherapy based on precise peptide self-assembly design

Article information

Article type
Feature Article
Submitted
11 nóv. 2021
Accepted
10 jan. 2022
First published
11 jan. 2022

Chem. Commun., 2022,58, 2247-2258

Supramolecular cancer photoimmunotherapy based on precise peptide self-assembly design

Y. Liu, L. Zhang, R. Chang and X. Yan, Chem. Commun., 2022, 58, 2247 DOI: 10.1039/D1CC06355C

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