Issue 4, 2021

The chronological evolution of small organic molecular fluorescent probes for thiols

Abstract

Abnormal concentrations of biothiols such as cysteine, homocysteine and glutathione are associated with various major diseases. In biological systems, the structural similarity and functional distinction of these three small molecular thiols has not only required rigorous molecular design of the fluorescent probes used to detect each thiol specifically, but it has also inspired scientists to uncover the ambiguous biological relationships between these bio-thiols. In this minireview, we will discuss the evolution of small organic molecular fluorescent probes for the detection of thiols over the past 60 years, highlighting the potent methodologies used in the design of thiol probes and their particular applications in the semi-quantification of cellular thiols and real-time labelling. At the same time, the present challenges that limit their further application will be discussed. We hope that this minireview will promote future research to enable deeper insight into the crucial role of thiols in biological systems.

Graphical abstract: The chronological evolution of small organic molecular fluorescent probes for thiols

Supplementary files

Article information

Article type
Review Article
Submitted
08 sep. 2020
Accepted
13 nóv. 2020
First published
15 des. 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2021,12, 1220-1226

The chronological evolution of small organic molecular fluorescent probes for thiols

Y. Yue, F. Huo and C. Yin, Chem. Sci., 2021, 12, 1220 DOI: 10.1039/D0SC04960C

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