Issue 4, 2021

Metal-free multicomponent approach for the synthesis of propargylamine: a review

Abstract

Propargylamines are important classes of alkyne coupled amine compounds used in heterocyclic chemistry and pharmaceuticals chemistry and have a large impact as a pharmacophore used in medicinal chemistry. One of the straightforward approaches for the synthesis of this class of compound is A3 coupling, a three-component coupling reaction among aldehyde, alkyne (terminal acetylene) and amine. However, there are many methods other than conventional three component alkyne–aldehyde–amine (A3) coupling which have also been reported for the synthesis of propargylamine. Most of these methods are based on the metal catalyzed activation of terminal alkyne. From the perspective of green and sustainable chemistry, the scientific community should necessarily focus on metal-free techniques which can access a variety of propargylamines. There are only a few reports found in the literature where propargylamines were successfully synthesized under metal-free conditions. This present review article neatly and precisely encompasses the comprehensive study of metal-free protocols in propargylamine synthesis putting forth their mechanisms and other aspects.

Graphical abstract: Metal-free multicomponent approach for the synthesis of propargylamine: a review

Article information

Article type
Review Article
Submitted
04 nóv. 2020
Accepted
14 des. 2020
First published
07 jan. 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 2047-2065

Metal-free multicomponent approach for the synthesis of propargylamine: a review

S. Ghosh and K. Biswas, RSC Adv., 2021, 11, 2047 DOI: 10.1039/D0RA09392K

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