Issue 10, 2021

Fluorescent labeling of biocompatible block copolymers: synthetic strategies and applications in bioimaging

Abstract

Among biocompatible materials, block copolymers (BCPs) possess several advantages due to the control of their chemistry and the possibility of combining various blocks with defined properties. Consequently, BCPs drew considerable attention as biocompatible materials in the fields of drug delivery, medicine and bioimaging. Fluorescent labeling of BCPs quickly appeared to be a method of choice to image and track these materials in order to better understand the nature of their interactions with biological media. However, incorporating fluorescent markers (FM) into BCPs can appear tricky; we thus intend to help chemists in this endeavor by reviewing recent advances made in the last 10 years. With the choice of the FM being of prior importance, we first reviewed their photophysical properties and functionalities for optimal labeling and imaging. In the second part the different chemical approaches that have been used in the literature to fluorescently label BCPs have been reviewed. We also report and discuss relevant applications of fluorescent BCPs in bioimaging.

Graphical abstract: Fluorescent labeling of biocompatible block copolymers: synthetic strategies and applications in bioimaging

Article information

Article type
Review Article
Submitted
05 feb. 2021
Accepted
04 apr. 2021
First published
06 apr. 2021
This article is Open Access
Creative Commons BY license

Mater. Adv., 2021,2, 3213-3233

Fluorescent labeling of biocompatible block copolymers: synthetic strategies and applications in bioimaging

S. Bou, A. S. Klymchenko and M. Collot, Mater. Adv., 2021, 2, 3213 DOI: 10.1039/D1MA00110H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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