Issue 39, 2020

Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy

Abstract

Semiconducting polymer nanoparticles (SPNs) have gained growing attention in biomedical applications. However, the preparation of SPNs is usually limited to nanoprecipitation in the presence of amphiphilic copolymers, which encounters the issue of dissociation. As an alternative to SPNs, grafted semiconducting polymer amphiphiles (SPAs) composed of a semiconducting polymer (SP) backbone and hydrophilic side chains show increased physiological stability and improved optical properties. This review summarizes recent advances in SPAs for cancer imaging and combination phototherapy. The applications of SPAs in optical imaging including fluorescence, photoacoustic, multimodal and activatable imaging are first described, followed by the discussion of applications in imaging-guided phototherapy and combination therapy, light-triggered drug delivery and gene regulation. At last, the conclusion and future prospects in this field are discussed.

Graphical abstract: Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy

Article information

Article type
Perspective
Submitted
25 mar. 2020
Accepted
15 júl. 2020
First published
15 júl. 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 10553-10570

Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy

C. Xie, W. Zhou, Z. Zeng, Q. Fan and K. Pu, Chem. Sci., 2020, 11, 10553 DOI: 10.1039/D0SC01721C

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