Issue 3, 2020

Activatable molecular agents for cancer theranostics

Abstract

Theranostics that integrates diagnosis and treatment modalities has attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome. Such a theranostic paradigm requires agents to simultaneously possess the capabilities of targeting, imaging, and treatment. Activatable molecular agents (AMAs) are promising for cancer theranostics, as they show a higher signal-to-noise ratio (SNR), real-time detection of cancer-associated biomarkers, lower normal tissue toxicity, and a higher therapeutic effect. This perspective summarizes the recent advancements of AMAs, which include imaging-guided chemotherapy, imaging-guided photodynamic therapy, and imaging-guided photothermal therapy. The molecular design principles, theranostic mechanisms, and biomedical applications of AMAs are described, followed by a discussion of potential challenges of AMAs in cancer theranostics.

Graphical abstract: Activatable molecular agents for cancer theranostics

Article information

Article type
Perspective
Submitted
30 okt. 2019
Accepted
22 nóv. 2019
First published
22 nóv. 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 618-630

Activatable molecular agents for cancer theranostics

J. Zhang, L. Ning, J. Huang, C. Zhang and K. Pu, Chem. Sci., 2020, 11, 618 DOI: 10.1039/C9SC05460J

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