Issue 5, 2020

Therapeutic potential of dithiocarbamate supported gold compounds

Abstract

Chrysotherapy or aurotherapy, the use of gold as medicine, is two thousand years old. Hitherto, numerous diverse gold stabilizing ligands for instance vitamins, pyridine, phosphines, naphthylamine and xanthanes have been developed and their ‘chelating effect’ in addition to their anti-proliferative properties have been extensively studied. Recent advances in the field of bioinorganic chemistry have led to the design of biologically relevant metal complexes with appropriate fine-tuned ligands such as metallic conjugates of dithiocarbamates (DTCs). DTC compounds have been recognised to possess diverse applications and have demonstrated interesting biological properties. For instance, the chemoprotective and antitumour properties of gold metal ions and DTC compounds respectively, presents an innovative and effective approach to cancer management. This review presents therefore the therapeutic potential of DTC ligand systems as a support for gold compounds. The importance of dithiocarbamate supported gold compounds as potential therapeutic agents is highlighted with emphasis on the therapeutic potential of gold(III) and gold(I) dithiocarbamate derivatives.

Graphical abstract: Therapeutic potential of dithiocarbamate supported gold compounds

Article information

Article type
Review Article
Submitted
19 nóv. 2019
Accepted
08 jan. 2020
First published
16 jan. 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 2975-2988

Therapeutic potential of dithiocarbamate supported gold compounds

C. K. Adokoh, RSC Adv., 2020, 10, 2975 DOI: 10.1039/C9RA09682E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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