Issue 19, 2020

Iodide-doped precious metal nanoparticles: measuring oxidative stress in vivo via photoacoustic imaging

Abstract

Accumulation of reactive oxygen and nitrogen species (RONS) can induce cell damage and even cell death. RONS are short-lived species, which makes direct, precise, and real-time measurement difficult. Biologically-relevant RONS levels are in the nM–μM scale; hence, there is a need for highly sensitive RONS probes. We previously used hybrid gold-core silver-shell nanoparticles with mM sensitivity to H2O2. These particles reported the presence of RONS via spectral shifts which could easily be quantified via photoacoustic imaging. Here, we used halide doping to tune the electrochemical properties of these materials to better match the oxidation potential of RONS. This work describes the synthesis, characterization, and application of these AgI-coated gold nanorods (AgI/AuNR). The I : Ag molar ratio, pH, and initial Ag shell thickness were optimized for good RONS detection limits. Halide doping lowers the reduction potential of Ag from Image ID:d0nr03047c-t1.gif to Image ID:d0nr03047c-t2.gif resulting in a 1000-fold increase in H2O2 and 100 000-fold increase in ONOO sensitivity. The AgI/AuNR system also etches 45-times faster than undoped Ag/AuNR. The AgI/AuNR easily reported the endogenously produced RONS in established cells lines as well as murine models.

Graphical abstract: Iodide-doped precious metal nanoparticles: measuring oxidative stress in vivo via photoacoustic imaging

Supplementary files

Article information

Article type
Communication
Submitted
10 mar. 2020
Accepted
27 apr. 2020
First published
27 apr. 2020

Nanoscale, 2020,12, 10511-10520

Author version available

Iodide-doped precious metal nanoparticles: measuring oxidative stress in vivo via photoacoustic imaging

Y. Mantri, B. Davidi, J. E. Lemaster, A. Hariri and J. V. Jokerst, Nanoscale, 2020, 12, 10511 DOI: 10.1039/D0NR03047C

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