Issue 6, 2020

3D multiphoton lithography using biocompatible polymers with specific mechanical properties

Abstract

The fabrication of two- and three-dimensional scaffolds mimicking the extracellular matrix and providing cell stimulation is of high importance in biology and material science. We show two new, biocompatible polymers, which can be 3D structured via multiphoton lithography, and determine their mechanical properties. Atomic force microscopy analysis of structures with sub-micron feature sizes reveals Young's modulus values in the 100 MPa range. Assessment of biocompatibility of the new resins was done by cultivating human umbilical vein endothelial cells on two-dimensionally structured substrates for four days. The cell density and presence of apoptotic cells has been quantified.

Graphical abstract: 3D multiphoton lithography using biocompatible polymers with specific mechanical properties

Supplementary files

Article information

Article type
Paper
Submitted
24 feb. 2020
Accepted
07 maí 2020
First published
09 maí 2020
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2020,2, 2422-2428

3D multiphoton lithography using biocompatible polymers with specific mechanical properties

B. Buchroithner, D. Hartmann, S. Mayr, Y. J. Oh, D. Sivun, A. Karner, B. Buchegger, T. Griesser, P. Hinterdorfer, T. A. Klar and J. Jacak, Nanoscale Adv., 2020, 2, 2422 DOI: 10.1039/D0NA00154F

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