Issue 9, 2020

Development of Fe3O4 integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

Abstract

Magnetic nanoparticle (MNP) integrated biomimetic scaffolds are receiving a lot of attention for the repair of bone defects and in bone tissue engineering applications. In the present work, Fe3O4 MNP integrated polymer/phosphate glass (CG/PG/MNP) composite scaffolds developed using a freeze drying technique are reported. MNP integrated CG/PG composite scaffolds were highly porous in nature with pores of size ranging between 20 and 150 μm and the pores were typically interconnected. Integration of Fe3O4 with CG/PG significantly influenced the swelling and degradation behavior constructively. The CG/PG/MNP composite scaffold exhibited a soft ferromagnetic nature and the compressive modulus increased significantly with increasing MNP content. In addition, the MNP containing CG/PG composite scaffolds demonstrated good bioactivity and cytocompatibility. Based on the results, MNP integrated CG/PG composite scaffolds developed in the present study may be potential scaffolds for bone tissue engineering applications.

Graphical abstract: Development of Fe3O4 integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

Associated articles

Article information

Article type
Paper
Submitted
20 júl. 2020
Accepted
12 okt. 2020
First published
13 okt. 2020
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2020,1, 3466-3475

Development of Fe3O4 integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

R. Govindan, S. Karthi, G. S. Kumar and E. K. Girija, Mater. Adv., 2020, 1, 3466 DOI: 10.1039/D0MA00525H

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