Issue 37, 2019

Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy

Abstract

Combination therapy with multiple chemotherapeutic agents is the main approach for cancer treatment in the clinic. Polyphenol-based materials are found in our diet, demonstrate good biocompatibility, and prevent numerous diseases. In this study, we encapsulate two drugs in a single polyphenol-based polymer with Fe3+ or Mn2+ ions as the cross-linker for cancer therapy. The combination index of two drugs is an essential parameter to evaluate drug combinations. The amphiphilic polymer poly(ethylene glycol)-block-polydopamine (PEG–PDA) was prepared by RAFT polymerization. The nanoparticles were prepared via self-assembly with Fe3+ or Mn2+ ions. Both doxorubicin (DOX) and simvastatin (SV) were encapsulated in the core of the nanoparticles. The cell viability and combination index were evaluated in vitro. The tumor accumulation of the nanoparticles was investigated by positron-emission tomography (PET) and magnetic resonance (MR) imaging. The as-prepared nanoparticles exhibited high drug loading capacity. The drug loaded nanoparticles could kill cancer cells effectively with a combination index <1. Both PET and MRI revealed that the nanoparticles showed long blood circulation time and high tumor accumulation. The nanoparticles could inhibit tumor inhibition via intravenous injection of nanoparticles. The polyphenol-based nanoplatform may serve as a promising theranostic candidate for clinical application.

Graphical abstract: Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy

Supplementary files

Article information

Article type
Paper
Submitted
31 júl. 2019
Accepted
22 ágú. 2019
First published
24 ágú. 2019

J. Mater. Chem. B, 2019,7, 5688-5694

Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy

J. Wang, W. Sang, Z. Yang, Z. Shen, Z. Wang, O. Jacobson, Y. Chen, Y. Wang, M. Shao, G. Niu, Y. Dai and X. Chen, J. Mater. Chem. B, 2019, 7, 5688 DOI: 10.1039/C9TB01597C

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