Issue 19, 2019

Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group

Abstract

The nickel(II)-catalyzed ortho-arylation of unactivated C–H bonds utilizing amino acids as directing groups with aryl iodides or bromides as coupling electrophiles is described. This protocol features excellent mono-selectivity, good regioselectivity, and wide functional group tolerance. Additionally, the obtained products bearing a biaryl motif and an amino acid represent bioactive molecules with wide bioactivities.

Graphical abstract: Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group

Supplementary files

Article information

Article type
Paper
Submitted
28 jan. 2019
Accepted
27 mar. 2019
First published
08 apr. 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 10820-10824

Ni(II)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group

Z. Cong, F. Gao and H. Liu, RSC Adv., 2019, 9, 10820 DOI: 10.1039/C9RA00749K

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