Issue 91, 2019

Palladium-catalyzed regioselective C–H alkynylation of indoles with haloalkynes: access to functionalized 7-alkynylindoles

Abstract

A palladium-catalyzed uniquely regioselective C–H alkynylation of indoles has been described. In this protocol, simple and readily available haloalkynes are employed as efficient alkynylating reagents, affording a series of functionalized 7-alkynylindoles in moderate to good yields. Moreover, further transformations of 7-alkynylated products were performed, which demonstrated the potential application of this method in organic synthesis.

Graphical abstract: Palladium-catalyzed regioselective C–H alkynylation of indoles with haloalkynes: access to functionalized 7-alkynylindoles

Supplementary files

Article information

Article type
Communication
Submitted
16 sep. 2019
Accepted
21 okt. 2019
First published
23 okt. 2019

Chem. Commun., 2019,55, 13769-13772

Palladium-catalyzed regioselective C–H alkynylation of indoles with haloalkynes: access to functionalized 7-alkynylindoles

S. Fang, G. Jiang, M. Li, Z. Liu, H. Jiang and W. Wu, Chem. Commun., 2019, 55, 13769 DOI: 10.1039/C9CC07263B

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