Issue 12, 2018

Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?

Abstract

Mechanochemistry is becoming more widespread as a technique for molecular synthesis with new mechanochemical reactions being discovered at increasing frequency. Whilst mechanochemical methods are solvent free and can therefore lead to improved sustainability metrics, it is more likely that the significant differences between reaction outcomes, reaction selectivities and reduced reaction times will make it a technique of interest to synthetic chemists. Herein, we provide an overview of mechanochemistry reaction examples, with ‘direct’ comparators to solvent based reactions, which collectively seemingly show that solid state grinding can lead to reduced reaction times, different reaction outcomes in product selectivity and in some instances different reaction products, including products not accessible in solution.

Graphical abstract: Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?

Article information

Article type
Perspective
Submitted
18 des. 2017
Accepted
26 feb. 2018
First published
07 mar. 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2018,9, 3080-3094

Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?

Joseph L. Howard, Q. Cao and D. L. Browne, Chem. Sci., 2018, 9, 3080 DOI: 10.1039/C7SC05371A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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