Issue 27, 2018

One-pot synthesis of chiral alcohols from alkynes by CF3SO3H/ruthenium tandem catalysis

Abstract

A practical one-pot synthesis of chiral alcohols from readily available alkynes via tandem catalysis by the combination of CF3SO3H and a fluorinated chiral diamine Ru(II) complex in aqueous CF3CH2OH is described. Very interestingly, the combination of fluorinated catalysts and solvent exhibits a positive fluorine effect on the reactivity and enantioselectivity. A range of chiral alcohols with wide functional group tolerance was obtained in high yield and excellent stereoselectivity under simple and mild conditions.

Graphical abstract: One-pot synthesis of chiral alcohols from alkynes by CF3SO3H/ruthenium tandem catalysis

Supplementary files

Article information

Article type
Paper
Submitted
14 mar. 2018
Accepted
12 apr. 2018
First published
19 apr. 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 14829-14832

One-pot synthesis of chiral alcohols from alkynes by CF3SO3H/ruthenium tandem catalysis

H. Liu, S. Liu, H. Zhou, Q. Liu and C. Wang, RSC Adv., 2018, 8, 14829 DOI: 10.1039/C8RA02224K

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