Issue 3, 2018

Organocatalytic asymmetric synthesis of cornolactones A and B, and formal synthesis of brasoside and littoralisone

Abstract

The asymmetric total synthesis of cornolactones A and B as well as the formal asymmetric synthesis of brasoside and littoralisone were accomplished in short steps, from simple starting materials. The key features of the synthesis include an efficient organocatalytic access to cyclopentenal 15, an intramolecular Michael addition reaction and an intramolecular oxa-Diels–Alder reaction.

Graphical abstract: Organocatalytic asymmetric synthesis of cornolactones A and B, and formal synthesis of brasoside and littoralisone

Supplementary files

Article information

Article type
Research Article
Submitted
17 sep. 2017
Accepted
03 okt. 2017
First published
11 okt. 2017

Org. Chem. Front., 2018,5, 358-360

Organocatalytic asymmetric synthesis of cornolactones A and B, and formal synthesis of brasoside and littoralisone

H. Hou, Q. Gu, X. Wang, D. Sun and B. Sun, Org. Chem. Front., 2018, 5, 358 DOI: 10.1039/C7QO00843K

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