Issue 13, 2018

Maximizing the impact of microphysiological systems with in vitroin vivo translation

Abstract

Microphysiological systems (MPS) hold promise for improving therapeutic drug approval rates by providing more physiological, human-based, in vitro assays for preclinical drug development activities compared to traditional in vitro and animal models. Here, we first summarize why MPSs are needed in pharmaceutical development, and examine how MPS technologies can be utilized to improve preclinical efforts. We then provide the perspective that the full impact of MPS technologies will be realized only when robust approaches for in vitroin vivo (MPS-to-human) translation are developed and utilized, and explain how the burgeoning field of quantitative systems pharmacology (QSP) can fill that need.

Graphical abstract: Maximizing the impact of microphysiological systems with in vitro–in vivo translation

Article information

Article type
Perspective
Submitted
14 jan. 2018
Accepted
12 maí 2018
First published
04 jún. 2018
This article is Open Access
Creative Commons BY-NC license

Lab Chip, 2018,18, 1831-1837

Maximizing the impact of microphysiological systems with in vitroin vivo translation

M. Cirit and C. L. Stokes, Lab Chip, 2018, 18, 1831 DOI: 10.1039/C8LC00039E

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