Issue 10, 2017

Concise asymmetric total synthesis of (−)-patchouli alcohol

Abstract

The asymmetric total synthesis of (−)-patchouli alcohol was accomplished in a concise manner. Key reactions include a highly diastereo- and enantioselective formal organocatalytic [4 + 2] cycloaddition reaction, a radical denitration reaction, and an oxidative carboxylation reaction. The formal synthesis of norpatchoulenol was achieved as well.

Graphical abstract: Concise asymmetric total synthesis of (−)-patchouli alcohol

Supplementary files

Article information

Article type
Research Article
Submitted
10 jún. 2017
Accepted
07 júl. 2017
First published
07 júl. 2017
This article is Open Access
Creative Commons BY-NC license

Org. Chem. Front., 2017,4, 2031-2033

Concise asymmetric total synthesis of (−)-patchouli alcohol

G. Xu, G. Lin and B. Sun, Org. Chem. Front., 2017, 4, 2031 DOI: 10.1039/C7QO00459A

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