Issue 1, 2017

Broccoli sprouts in analgesia – preclinical in vivo studies

Abstract

Background: Broccoli is a rich source of health-promoting glucosinolates, phenolic compounds, minerals and vitamins, which might have potential to alleviate pain. Aim: To explore the antinociceptive effects of a broccoli sprout aqueous extract (BSE) in experimental models of pain and an opioid mechanism. Materials and methods: the BSE was administered to mice and rats that were subjected to the writhing and formalin tests, respectively. Gastric damage or sedative-like response, as adverse effects observed in anti-inflammatory non-steroidal and opioid analgesic drugs, respectively, were also explored. Results: Antinociception, but not sedative or gastric injury response, was observed in a significant and dose-dependent manner with the BSE (50–500 mg kg−1, i.p. and 500–2000 mg kg−1, p.o.) in comparison to the control group; these effects resembled those observed with the analgesic tramadol (30 mg kg−1, i.p.) in writhing and formalin assessments. Blockage of opioid receptors by naloxone (1 mg kg−1, i.p.) produced partial inhibition of the antinociceptive effect of the BSE in both assays. Conclusion: This study gives evidence of the potential activity of broccoli sprouts in pain therapy.

Graphical abstract: Broccoli sprouts in analgesia – preclinical in vivo studies

Article information

Article type
Paper
Submitted
11 okt. 2016
Accepted
21 nóv. 2016
First published
25 nóv. 2016

Food Funct., 2017,8, 167-176

Broccoli sprouts in analgesia – preclinical in vivo studies

N. Baenas, M. E. González-Trujano, O. Guadarrama-Enríquez, F. Pellicer, C. García-Viguera and D. A. Moreno, Food Funct., 2017, 8, 167 DOI: 10.1039/C6FO01489E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements