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Issue 83, 2016
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Hybrid bicelles as a pH-sensitive nanocarrier for hydrophobic drug delivery

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Abstract

Hydrophobic doxorubicin was successfully loaded into hybrid discoid bicelles generated from proamphiphilic organoalkoxysilane and dihexanoyl phosphatidylcholine at the ratio of 7 : 2 by conventional Bangham method in combination with sol–gel reaction and self-assembly process. The drug-loaded hybrid bicelles with about 60 nm diameter and 6 nm thickness were found to exhibit pH-sensitive release behavior, good biocompatibility and remarkably high stability towards surfactant solubilization, long-term storage, and many factors susceptible to destabilize conventional phospholipid bicelles. The hybrid bicelles were proved to have higher cellular uptake via endocytosis and adhesion than spherical cerasomes. The endocytosis of hybrid bicelles was related to clathrin, macropinocytosis and was energy-dependent. Both in vitro and in vivo results showed that the drug loaded bicelles can effectively inhibit tumor growth. In other words, such hybrid bicelles can be employed as a novel promising nanocarrier for hydrophobic drugs.

Graphical abstract: Hybrid bicelles as a pH-sensitive nanocarrier for hydrophobic drug delivery

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Publication details

The article was received on 16 júl. 2016, accepted on 15 ágú. 2016 and first published on 17 ágú. 2016


Article type: Paper
DOI: 10.1039/C6RA18112K
RSC Adv., 2016,6, 79811-79821

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    Hybrid bicelles as a pH-sensitive nanocarrier for hydrophobic drug delivery

    L. Lin, X. Wang, Y. Guo, K. Ren, X. Li, L. Jing, X. Yue, Q. Zhang and Z. Dai, RSC Adv., 2016, 6, 79811
    DOI: 10.1039/C6RA18112K

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