Issue 1, 2016

Asymmetric total synthesis of Lycopodium alkaloids α-obscurine, N-desmethyl-α-obscurine, β-obscurine and N-desmethyl-β-obscurine

Abstract

The asymmetric total synthesis of α-obscurine (1), β-obscurine (2), N-desmethyl-α-obscurine (3), and N-desmethyl-β-obscurine (4) was accomplished. Key reactions in the construction of the A/B/C-ring system include the Buchwald–Hartwig coupling reaction, the Heck cyclization, and the diastereoselective hydrogenation.

Graphical abstract: Asymmetric total synthesis of Lycopodium alkaloids α-obscurine, N-desmethyl-α-obscurine, β-obscurine and N-desmethyl-β-obscurine

Supplementary files

Article information

Article type
Research Article
Submitted
06 nóv. 2015
Accepted
17 nóv. 2015
First published
18 nóv. 2015

Org. Chem. Front., 2016,3, 62-65

Asymmetric total synthesis of Lycopodium alkaloids α-obscurine, N-desmethyl-α-obscurine, β-obscurine and N-desmethyl-β-obscurine

J. Fu, G. Xu, R. Ding, G. Lin and B. Sun, Org. Chem. Front., 2016, 3, 62 DOI: 10.1039/C5QO00355E

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