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Issue 5, 2016
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Mechanochemical functionalization of disulfide linked hydrogels

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Abstract

Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force. Compression or tension induces bond rupture at the relatively weak disulfide linkages, which will subsequently react through Michael-type addition with an acceptor molecule within the gel. We demonstrate the utility of this approach by patterning cell adhesion proteins through compression of a lithographically structured stamp, where cells predominately adhere to the compressed regions.

Graphical abstract: Mechanochemical functionalization of disulfide linked hydrogels

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Publication details

The article was received on 30 mar. 2016, accepted on 26 maí 2016 and first published on 02 jún. 2016


Article type: Communication
DOI: 10.1039/C6MH00091F
Citation: Mater. Horiz., 2016,3, 447-451

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    Mechanochemical functionalization of disulfide linked hydrogels

    J. Lee, M. N. Silberstein, A. A. Abdeen, S. Y. Kim and K. A. Kilian, Mater. Horiz., 2016, 3, 447
    DOI: 10.1039/C6MH00091F

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