Issue 85, 2015

DMSO affects Aβ1–40's conformation and interactions with aggregation inhibitors as revealed by NMR

Abstract

We show via 3D-heteronuclear NMR spectroscopy that Aβ1–40 adopts a disordered conformational ensemble with fluctuating turns in DMSOd6. Using NMR, we map the binding sites of three water-insoluble aggregation inhibitors to Aβ1–40 in DMSOd6 and discover remarkable differences in Aβ1–40 recognition by a fourth inhibitor in H2O versus DMSOd6.

Graphical abstract: DMSO affects Aβ1–40's conformation and interactions with aggregation inhibitors as revealed by NMR

Supplementary files

Article information

Article type
Communication
Submitted
23 jún. 2015
Accepted
10 ágú. 2015
First published
10 ágú. 2015

RSC Adv., 2015,5, 69761-69764

Author version available

DMSO affects Aβ1–40's conformation and interactions with aggregation inhibitors as revealed by NMR

D. V. Laurents, D. Pantoja-Uceda, L. C. López, J. A. Carrodeguas, M. Mompeán, M. Á. Jiménez and J. Sancho, RSC Adv., 2015, 5, 69761 DOI: 10.1039/C5RA12100K

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