Jump to main content
Jump to site search

Issue 97, 2015
Previous Article Next Article

The copper binding properties of metformin – QCM-D, XPS and nanobead agglomeration

Author affiliations

Abstract

Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and L-cysteine–copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.

Graphical abstract: The copper binding properties of metformin – QCM-D, XPS and nanobead agglomeration

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 maí 2015, accepted on 07 sep. 2015 and first published on 07 sep. 2015


Article type: Communication
DOI: 10.1039/C5CC04321B
Author version
available:
Download author version (PDF)
Citation: Chem. Commun., 2015,51, 17313-17316
  •   Request permissions

    The copper binding properties of metformin – QCM-D, XPS and nanobead agglomeration

    X. Quan, R. Uddin, A. Heiskanen, M. Parmvi, K. Nilson, M. Donolato, M. F. Hansen, G. Rena and A. Boisen, Chem. Commun., 2015, 51, 17313
    DOI: 10.1039/C5CC04321B

Search articles by author

Spotlight

Advertisements