Issue 29, 2015

Fluorescent sensing of monofunctional platinum species

Abstract

We report here FDCPt1, a novel selective fluorescent sensor for monofunctional platinum species. In the presence of such species, FDCPt1 exhibits a 70-fold increase in fluorescence emission, and can be used to monitor the metabolism of Pt(II)-based complexes in colorectal cancer cells. This probe is therefore expected to be valuable in studying changes in Pt coordination and distribution during chemotherapy.

Graphical abstract: Fluorescent sensing of monofunctional platinum species

Supplementary files

Article information

Article type
Communication
Submitted
13 okt. 2014
Accepted
04 mar. 2015
First published
11 mar. 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 6312-6314

Fluorescent sensing of monofunctional platinum species

C. Shen, B. D. W. Harris, L. J. Dawson, K. A. Charles, T. W. Hambley and E. J. New, Chem. Commun., 2015, 51, 6312 DOI: 10.1039/C4CC08077G

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