K2CO3-mediated, direct C–H bond selenation and thiolation of 1,3,4-oxadiazoles in the absence of metal catalyst: an eco-friendly approach

Abstract

An eco-friendly, straightforward and high-yielding methodology for the synthesis of chalcogenyl oxadiazoles via the K₂CO₃-promoted direct C–H bond chalcogenation of 2-substituted-1,3,4-oxadiazoles is described herein. The reaction was performed in the absence of metal catalyst and inert atmosphere using only half an equiv. of dichalcogenide and a low-cost base.