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Issue 5, 2014
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Integrating a thermoresponsive copolymer with host–guest interactions for fabricating molecular recognition surfaces

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Abstract

A platform capable of integrating variable molecular recognition moieties, having tunable function and regenerable/reusable ability has been developed to build bio-functional surfaces. More specifically, mannose and biotin-modified β-CD were incorporated into poly(N-isopropylacrylamide-co-1-adamantan-1-ylmethyl acrylate) [poly(NIPAAm-co-Ada)] surfaces by host–guest interactions to investigate their specific interaction with ConA and avidin, respectively. The surfaces have showed thermoresponsively tunable recognition for specific proteins, while showing resistance to nonspecific protein adsorption. By varying the Ada content, the regulation of specific protein adsorption in different temperature ranges could be achieved. The poly(NIPAAm-co-Ada) surfaces can be easily regenerated and reused for bio-functionalization.

Graphical abstract: Integrating a thermoresponsive copolymer with host–guest interactions for fabricating molecular recognition surfaces

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Article information


Submitted
17 maí 2014
Accepted
16 jún. 2014
First published
16 jún. 2014

Mater. Horiz., 2014,1, 540-545
Article type
Communication
Author version available

Integrating a thermoresponsive copolymer with host–guest interactions for fabricating molecular recognition surfaces

X. Shi, G. Chen, L. Yuan, Z. Tang, W. Liu, Q. Zhang, D. M. Haddleton and H. Chen, Mater. Horiz., 2014, 1, 540
DOI: 10.1039/C4MH00081A

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