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Issue 37, 2011
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Efficient and facile formation of two-component nanoparticlesvia aromatic moiety directed self-assembly

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Abstract

Here we present a two-component self-assembling system employing the interaction of aromatic groups (Fmoc) to construct nanoparticles. Spherical particles of around 70 nm were formed spontaneously by a simple trigonal Fmoc-conjugate, which were then stabilized by Fmoc-dipeptides at physiological pH in aqueous solution. These novel particles, being well-tolerated by cells, capable of encapsulating hydrophobic compounds, and readily decorated by short peptides, are promising carriers for drug delivery.

Graphical abstract: Efficient and facile formation of two-component nanoparticlesvia aromatic moiety directed self-assembly

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Article information


Submitted
22 feb. 2011
Accepted
08 apr. 2011
First published
26 apr. 2011

Chem. Commun., 2011,47, 10224-10226
Article type
Communication

Efficient and facile formation of two-component nanoparticlesvia aromatic moiety directed self-assembly

W. Wang and Y. Chau, Chem. Commun., 2011, 47, 10224
DOI: 10.1039/C1CC11048A

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