Issue 40, 2023

A mechanical biosensor based on membrane-mediated magneto-stress-electric coupled sensitization for human serum albumin detection

Abstract

Recently, mechanical biosensors have attracted more attention on single molecule detection due to its high accuracy, low cost, and convenience. However, the sensitivity of the mechanical biosensors restricted their clinical application. Herein, a mechanical biosensor based on membrane-mediated magneto-stress-electric coupled sensitization (MSEC-MMB) was developed to enhance performance. Through introducing Fe3O4 nanoparticles (MNPs) to traditional stress-electric biosensors and applying a magnetic field, a magneto-stress-electric coupled biosensing system was constructed. The sensitivity of the MSEC-MMB was improved via enhancing the deformation of the mechanical membrane, which was demonstrated by detecting HSA. The optimal limit of detection (LOD) was 24 pg mL−1 under a magnetic field of 50 mT. The LOD was significantly 1 order of magnitude lower than that without the magnetic field. Besides, the MSEC-MMB showed a high specificity, selectivity, and stability. The clinical proteinuria samples were accurately detected, suggesting a good practicability of the MSEC-MMB. All these results proved the high sensitivity and practicality of the MSEC-MMB and provide a platform for early nephropathy diagnosis.

Graphical abstract: A mechanical biosensor based on membrane-mediated magneto-stress-electric coupled sensitization for human serum albumin detection

Supplementary files

Article information

Article type
Paper
Submitted
02 jún. 2023
Accepted
14 sep. 2023
First published
17 sep. 2023

J. Mater. Chem. B, 2023,11, 9658-9665

A mechanical biosensor based on membrane-mediated magneto-stress-electric coupled sensitization for human serum albumin detection

D. Zhao, P. Xiao, X. Dong, Y. Ge, X. Guo, J. Ji, Y. Cheng and S. Sang, J. Mater. Chem. B, 2023, 11, 9658 DOI: 10.1039/D3TB01268A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements