Issue 21, 2023

Recent advances in nanotechnology for combating Alzheimer's disease

Abstract

As the population ages, Alzheimer's disease (AD) has become a serious health problem worldwide. However, there is almost no effective method in the clinic for AD therapy due to the complicated pathogenesis and the multiple physiological barriers for brain drug delivery, especially the presence of the blood–brain barrier (BBB). Nowadays, nanotechnology has been explored for its great potential in brain drug delivery via improving bioavailability, overcoming the BBB, precise targeting and achieving drug co-delivery. In this review, we briefly introduce the widely studied targets of AD at first. Then, we summarize the recent advances in nanotechnology for AD treatment; strategies are broadly categorized according to the therapeutic targets, including toxic protein modulation, cell targeting in AD lesion sites or microenvironment modulation. Finally, the challenges and our perspectives for future directions of nanotechnology to combat AD are also discussed.

Graphical abstract: Recent advances in nanotechnology for combating Alzheimer's disease

Article information

Article type
Review Article
Submitted
30 apr. 2023
Accepted
11 júl. 2023
First published
31 júl. 2023

Mater. Chem. Front., 2023,7, 5171-5186

Recent advances in nanotechnology for combating Alzheimer's disease

C. Hu, B. Wu, Y. Wu, M. Shi, J. Ma, H. Gao and J. Zhang, Mater. Chem. Front., 2023, 7, 5171 DOI: 10.1039/D3QM00493G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements