Issue 23, 2020

Silica nanoparticle coated perfluorooctyl bromide for ultrasensitive MRI

Abstract

MRI with hyperpolarized 129Xe can achieve low-concentration detection. Herein, nanoparticle-coated perfluorooctyl bromide (PFOB) was developed as a 129Xe MRI contrast agent with a moderate exchange rate, sufficient stability and feasible surface modification. The αvβ3 integrin overexpressed by non-small-cell lung cancer A549 cells was successfully detected by 129Xe MRI with high specificity through adequate surface modifications.

Graphical abstract: Silica nanoparticle coated perfluorooctyl bromide for ultrasensitive MRI

Supplementary files

Article information

Article type
Communication
Submitted
21 feb. 2020
Accepted
07 apr. 2020
First published
07 apr. 2020

J. Mater. Chem. B, 2020,8, 5014-5018

Silica nanoparticle coated perfluorooctyl bromide for ultrasensitive MRI

Y. Yuan, Q. Guo, X. Zhang, W. Jiang, C. Ye and X. Zhou, J. Mater. Chem. B, 2020, 8, 5014 DOI: 10.1039/D0TB00484G

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