Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis
Abstract
Covering: up to the end of 2017
The roles played by Rieske non-heme iron-dependent oxygenases in natural product biosynthesis are reviewed, with particular focus on experimentally characterised examples. Enzymes belonging to this class are known to catalyse a range of transformations, including oxidative carbocyclisation, N-oxygenation, C-hydroxylation and C–C desaturation. Examples of such enzymes that have yet to be experimentally investigated are also briefly described and their likely functions are discussed.
- This article is part of the themed collection: Metalloenzymes in Natural Product Biosynthetic Pathways