A bridging coordination mode of urea and carbamate at a dinuclear nickel(II) centre

Abstract

Starting from an active O₂H₃-bridged bimetallic complex, a bridging coordination mode of both urea and carbamate—the substrate and its first hydrolytic product in urease activity—at a dinickel(II) centre relevant to the active site of the metalloenzyme has been characterised structurally.

References

1. R. K. Andrews, R. L. Blakeley and B. Zerner, in The Bioinorganic Chemistry of Nickel, ed. J. R. Lancaster, Jr., VCH, New York 1988.
2. E. Jabri, M. B. Carr, R. P. Hausinger and P. A. Karplus, Science, 1995, 268, 998.
3. (a) N. E. Dixon, P. W. Riddles, C. Gazzola, R. L. Blakeley and B. Zerner, Can. J. Biochem., 1980, 58, 1335; (b) S. J. Lippard, Science, 1995, 268, 996.
4. P. A. Karplus, M. A. Paerson and R. P. Hausinger, Acc. Chem. Res., 1997, 30, 330.
5. D. Volkmer, A. Hörstmann, K. Griesar, W. Haase and B. Krebs, Inorg. Chem., 1996, 35, 1132; D. Volkmer, B. Hommerich, K. Griesar, W. Haase and B. Krebs, Inorg. Chem., 1996, 35, 3792.
6. R. M. Buchanan, M. S. Mashuta, K. J. Oberhausen and J. F. Richardson, J. Am. Chem. Soc., 1989, 111, 4497.
7. (a) H. E. Wages, K. L. Taft and S. J. Lippard, Inorg. Chem., 1993, 32, 4985; (b) K. Yamaguchi, S. Koshino, F. Akagi, M. Suzuki, A. Uehara and S. Suzuki, J. Am. Chem. Soc., 1997, 119, 5752; (c) T. Koga, H. Furutachi, T. Nakamura, N. Fukita, M. Ohba, K. Takahashi and H. Okawa, Inorg. Chem., 1998, 37, 989.
8. F. Meyer, A. Jacobi, B. Nuber, P. Rutsch and L. Zsolnai, Inorg. Chem., 1998, 37, 1213.
9. (a) F. Meyer, S. Beyreuther, K. Heinze and L. Zsolnai, Chem. Ber./Recueil, 1997, 130, 605; (b) F. Meyer, K. Heinze, B. Nuber and L. Zsolnai, J. Chem. Soc., Dalton Trans., 1998, 207.
10. F. Meyer and P. Rutsch, Chem. Commun., 1998, 1037.
11. F. Meyer, E. Kaifer, H. Pritzkow, F. Rominger, K. Heinze and L. Zsolnai, manuscript in preparation.
12. N. V. Kaminskaia and N. M. Kostic, Inorg. Chem., 1997, 36, 5917.
13. L. Birkofer, A. Ritter and H. Dickopp, Chem. Ber., 1963, 96, 1473.
14. T. C. Woon, W. A. Wickramasinghe and D. P. Fairlie, Inorg. Chem., 1993, 32, 2190.
15. T. G. Schenck, J. M. Downes, C. R. C. Milne, P. B. Mackenzie, H. Boucher, J. Whelan and B. Bosnich, Inorg. Chem., 1985, 24, 2334.
16. G. M. Sheldrick, SHELXL-97, Program for Crystal Structure Refinement, Universität Göttingen, 1997; SHELXS-97, Program for Crystal Structure Solution, Universität Göttingen, 1997.