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DOI: 10.1039/P19960002371 (Paper) Reference Section for: J. Chem. Soc., Perkin Trans. 1, 1996, 2371-2377

Comparison of the substrate specificity of type I and type II dehydroquinases with 5-deoxy- and 4,5-dideoxy-dehydroquinic acid

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Joanna M. Harris, William J. Watkins, Alastair R. Hawkins, John R. Coggins and Chris Abell

Abstract

Syntheses of 5-deoxydehydroquinic acid and 4,5-dideoxydehydroquinic acid from quinic acid are described. These substrate analogues were tested against the mechanistically-distinct type I and type II dehydroquinases. The C-4 hydroxy group of the substrate is shown to be important for imine formation on the type I enzyme but appears not to contribute significantly to specificity on the type II dehydroquinase.

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