Synthetic potential of ynamides and ynamide-derived advanced intermediates in cycloaddition reactions with different reaction partners to yield versatile heterocyclic adducts.
The regioselectivity for gold(I)-catalyzed cycloisomerizations of tryptamine-ynamides was studied by DFT calculations. The electrostatic and dispersion effects were determined as key factors for the α- and β-position selectivity, respectively.
Silver catalysis offers environmentally friendly and simple protocols to construct N-heterocycles. Inspired by its appeal, herein we have summarized developments in the silver-catalyzed synthesis of N-heterocycles since 2019.
Amino-substituted benzofuran derivatives have attracted attention in recent years due to their remarkable biological activity.
This review summaries the advances in Au-catalyzed asymmetric alkyne transformations over the past two decades. It is organized by the key intermediates and the chirality induction models, offering a toolkit for the implement of asymmetric catalysis.