This perspective summarizes recent advances in α-peptoid polymers from synthesis to antimicrobial applications, and discusses current challenges and future directions in the development of antimicrobial poly(α-peptoid)s.
A novel switchable polymerization method enables the one-step/one-pot synthesis of well-defined polyester-b-polypeptoids from a monomer mixture of epoxides, cyclic anhydrides, and N-substituted N-carboxyanhydrides.
Rational design of sulfonium-based polypeptoids via optimization of structural parameters yields potent antimicrobials against drug-resistant bacteria with enhanced stability, rapid bactericidal efficacy and biofilm disrupting ability.
To address the issue of infection in interventional biomedical implants, we reported cost-effective cationic polypeptoids modified polyurethane (PU) films (PU-PNBM, PU-PNBE, PU-PNBB) to create physical-biological synergistic antibacterial surfaces.
We report a facile and efficient approach to prepare multifunctional bioinspired platforms under mild conditions that offer increased catalytic efficiency and stability.