Chemical design and synthesis of macromolecular profluorescent nitroxide systems as self-reporting probes

The objective of this mini-review article is to highlight derivatives of polymeric profluorescent nitroxides. Importantly, the limitations that restrict expansion of this class of polymers are discussed. The challenges of harsh conditions that lead to undesired side-reactions during polymerization or the necessity of orthogonal post–modification reactions are reviewed. Importantly, I discuss the challenges within this field, and suggest strategies for the advancement of polymeric profluorescent nitroxide derivatives.