Themed collection Functional Framework Materials for Biomedical Applications

Ross S. Forgan, Ruxandra Gref and Jianqiang Liu introduce the Journal of Materials Chemistry B themed collection on functional framework materials for biomedical applications.

This review discusses the functionalization strategies of ZIF-8 and challenges and future developments in ZIF-8-based platforms for drug delivery and cancer therapy.

This review explores the different types of nanozymes with POD-like activity and discusses their activity regulation, particularly emphasizing their latest development trends and advances in biosensing and disease treatment.

This review summarizes fabrication strategies and manifold applications of electrospun organic/inorganic hybrid nanofibers in promoting the wound healing process.

Over the past two decades, metal–organic frameworks (MOFs) have garnered substantial scientific interest across diverse fields, spanning gas storage, catalysis, biotechnology, and more.

Magnetic 2D nanocomposites exhibit advanced antitumor applications, including magnetically targeted hyperthermia, drug delivery, phototherapy, nanozyme therapy, immunotherapy and multimodal imaging.

ZIF-8 nanoparticles, with large surface area and pore capacity, can be functionalized for targeted cancer treatment. This enhances chemotherapeutic drug efficacy and potentially improves PD-1 inhibitors’ effectiveness.

This review highlights the recent advances of MOFs and their related hybrids in main implant intervention fields, while also discussing their confronting challenges and future perspectives.

Application and development of synthesized bio-MOFs via a green approach (solvent-free and solvent-based green syntheses) for targeted drug delivery and tumor treatment.

The emergence of ZIFs-based composite materials as promising candidates for electrochemical sensors of important small biomolecules in human body fluids.

Critical analysis of discrete metal compounds and metal–organic frameworks (MOFs) as a platform for the treatment and/or diagnosis of Alzheimer's disease.

This article reviews the recent developments in the use of MOF materials as probes and biosensing platforms for diverse chemicals (H₂O₂, metal ions, H₂S, GSH, and nucleic acids) in biological cells.

Metal–organic frameworks (MOFs) that comprise metal ions combined with assorted organic linkers have been utilized as tools in cancer therapy.

Reconstructing inflammatory bone defects using stem cell-based therapy faces challenges posed by the oxidative stress microenvironment.

pH-responsive sodium alginate/polyvinylpyrrolidone/Zr–metal organic framework composite for controlled lapatinib release and high biocompatibility in oral breast cancer therapy.

GOD@ZIF-7-III composites demonstrate 98% catalytic activity, improved pH and thermal stability, 66% storage retention, and efficient glucose detection in plasma, highlighting biosensing potential.

A cartoon, theoretical representation of a highly porous protein crystal that has been subjected to MOF growth conditions, highlighting the union of both the proteinaceous components and MOF components of the hybrid material.

Traditional tumor treatments focus on treating the location of the lesion, while immunogenic cell death (ICD) triggers systemic anti-tumor immunity and inhibits tumor metastasis.

Biomimetic ZIF-8/DOX nanoparticles, coated with Cucurbita-derived exosomes and functionalized with EpCAM aptamer, were developed to enhance biocompatibility and immune evasion, leading to targeted prostate cancer therapy.

Effectively managing infected diabetic wounds involves the elimination of bacteria, neutralization of reactive oxygen species (ROS), suppression of inflammation, and induction of angiogenesis.

Here we demonstrate the most reliable way to immobilize giant unilamellar vesicles (GUVs) using metal-organic frameworks (MOFs).

Bioactive ZIF-67 and ZIF-8 nanocarriers functionalized with saponin and apigenin demonstrate synergistic drug delivery and apoptosis induction, offering potential for targeted cancer nanotherapeutics with minimal side effects.

Luminescent NiMOF demonstrated remarkable capabilities in efficient, sensitive and intelligent detection of 3-NT biomarker and 6-PTU thyroid drug in urine through luminescence quenching effects.

An artificial nano-enzyme-enhanced hydrogel was developed to treat OA through a ternary synergistic strategy of efficiently driving O₂ production from endogenous ROS in chondrocytes and maintaining lubrication at the articular cartilage interface.

Metal organic frameworks (MOFs) have garnered significant attention in the development of stretchable and wearable conductive hydrogels for flexible transducers.

Ti-based metal–organic frameworks in the controlled and efficient release of insecticidal chlorogenic acid: an in vivo study.

The cubic metal nanoclusters, especially the smaller ones, exhibited stability when placed in 4 M [N1114][C1SO3] ionic liquid solution.

Synthesis strategy of glucose-responsive intelligent hydrogels based on multifunctional nanocomposite nodes and their mechanism in diabetic and infected diabetic wounds.

Designing wound dressings necessitates the crucial considerations of maintaining a moist environment and implementing effective bacterial control.

Microporous organic polymers (MOPs) and silver oxide (Ag₂O) hybrid composites do show good antimicrobial capabilities, making them flexible for a variety of applications.

A maximum GSH-depleting photodynamic nanosystem was developed by loading Cu²⁺ into porphyrin MOF. Both in vitro and in vivo results indicate MOF@Cu²⁺ could obliterate biofilm infection and facilitate wound healing with no distinct side effects.

Background: Multimodal cancer therapy has garnered significant interest due to its ability to target tumor cells from various perspectives.

A novel FL–ECL dual-mode sensor for apoE gene detection with ruthenium MOF nanosheets exhibits high sensitivity, wide linear ranges, and robust real-world application potential.

Porous materials based on robust rhodium-based metal–organic polyhedra have relevant NO payloads and release them in response to two different stimuli: light and humidity.

The multi-functional nanoparticle HN@Cu-MOF integrates PDT/CDT/GT, leading to a significant enhancement in GSH consumption and an elevation in ROS production, initiating the sensitization to PDT and cell apoptosis in the treatment of tumors.

A porphyrin–anthracene covalent organic framework for continuous release of singlet oxygen through both photosensitization and cycloreversion pathways was constructed for photosterilization and bacterial-infected wound healing.

Synthesis of IITI-3, INH encapsulation within IITI-3, their drug release, anti-mycobacterial activity and the mycobacterial biofilm inhibition phenomenon of INH@IITI-3.

The La-TCPP@DOX@Apt composite nanomaterial not only avoid the side effects caused by high concentration chemotherapeutic drugs, but also can effectively inhibit and kill solid tumors under the synergistic attack of CD and PDT.

A dual-functional nanocarrier was constructed via in situ crystallization with DOX drugs covalently connected to the surface of CuZn-ZIF for combining chemotherapy and chemodynamic therapy.

A new strategy of PEGylation over core–shell MOFs of HKUST-1 and Cu-MOF-2 by a solvothermal method.

One-step synthesis of gallium-based metal–organic frameworks loaded with antimicrobial peptides at room temperature for synergistic killing of drug-resistant bacteria.

This study investigated different secondary building units of iron-based metal–organic frameworks and discovered that when combined with an enzyme-encapsulating ZIF-90 PVP MOF, they could be sequentially employed for glucose detection purposes.

By combining the keratin and ZIF-8 particles, the problems of the poor mechanical properties and lack of antibacterial effect of the keratin sponge was solved. The released by Zn²⁺ form ZIF-8 acted as crosslinker to form Zn-S with sulfhydryl groups.

The dual ligand functionalization of UCNP and MOF assembly on multiple UCNPs to obtain nanohybrid UCMs.

The research direction of this manuscript is focused on osteogenesis through zeolitic imidazolate framework-8 (ZIF-8) loaded dexamethasone DEX. It is shown that DEX can induce osteogenic differentiation of rat bone marrow mesenchymal stem cells and promote osteogenesis in vitro and in vivo.

NanoMUV-2 stores high payloads of Paclitaxel and increases its anticancer selectivity.

A novel PEC and ECL bifunctional biosensor for the sensitive and selective detection of miRNA-126 based on the AgNPs@V-PMOF Schottky heterojunction was constructed.

Within hydrogen-bonded organic frameworks (HOFs), the stabilized charge transfer cocrystals, named TQC@PFC-1, exhibit high photothermal conversion efficiency in the NIR II region for photothermal therapy in both in vitro and in vivo settings.

We report a nanoprobe for highly sensitive detection of S. aureus, relying on a MOF-based FRET process.

The DOX@7FZ was able to enhance the ROS level in cancer cells via a synergistic effect between apoptosis/ferroptosis synergism.