Bicyclo[1.1.0]butanes (BCBs), characterized by their compact and highly strained carbocyclic frameworks, have emerged as versatile building blocks in modern synthetic chemistry.
This review primarily focuses on the latest developments in Lewis acid-catalyzed strain-release cycloaddition reactions of BCBs.
This tutorial review provides an overview of the important structural features and reactivity modes of BCBs and delves deep into the recent advances in BCB chemistry for the synthesis of bicyclic scaffolds and functionalized cyclobutanes.
This comprehensive review describes the methodologies reported between 2020 and early 2025 for the synthesis of (hetero)bicyclo[2.1.1]hexane derivatives, organised by mechanisms and the exit vectors achieved.
Bicyclo[1.1.0]butanes have beautiful conformations, distinctive properties, and novel reactivities. We summarize and highlight the recent advances of its photochemical strain-release reactions relying on SET or EnT strategies.