Synthesis and fabrication of redox-switchable polymeric lipid hybrid nanocarriers that selectively deliver berberine and induce apoptosis in GSH-rich cancer cells while sparing healthy cells.
The study summarizes the findings from the last eight years of research on heterocyclic core-based epidermal growth factor receptor inhibitors. This provides an invaluable tool for oncology drug discovery.
36 dibenzodiazepinone analogues were designed and synthesized, and their antiproliferative activities were evaluated. Compound 33 exhibited best inhibitory activity against Osimertinib resistant NSCLC cells.
The activatable fluorescence probe Q-Atezol demonstrates great potential as an exceptional sensor for assessing PD-L1 expression in three-dimensional cell structures and for in vivo applications.
Prospects of novel fourth-generation EGFR-TKIs overcoming C797S-mediated resistance in non-small cell lung cancer.