The rigidity and well-defined size and shape of the bispidine scaffold, as well as the ease of preparing 4- to 10-dentate ligands are the main features for its very rich coordination chemistry.
Here, we show a versatile design strategy based on bispidine. The conformational study of bispidine diamides showed that syn/anti-forms exist. The bispidine–amino acid conjugate behaves like a molecular machine with stops at the syn/anti-position.
In bispidine-iron(IV)–tosylimido complexes, axial vs. equatorial NTs coordination dictates the decay: axial gives a low-spin Fe(III)–NHTs, whereas equatorial yields a high-spin Fe(III) species via self-decay resulting in N-centered demethylation.
This review highlights recent advances in halogen bond across diverse chirality-related research fields, including crystallography, computational chemistry, supramolecular chemistry, organic synthetic chemistry, and biochemistry.
Halogen bonds (XBs) show preference toward hydrophobic microenvironments compared to hydrogen bonds (HBs). The interaction energies of HBs and XBs are decreased to varying degrees given their specific microenvironments.